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affected by ischemia is higher than the temperature in the unaffected parts of the brain and the rest of the body [33]. Clinical trials of therapeutic hypothermia in patients with ischemic stroke have been conducted based on observations that in animal models hypothermia reduces the size of cerebral infarcts by more than half [131]. Furthermore, in stroke patients, higher body temperature is associated with poorer outcome [4]. The processes that determine brain temperature after human ischemic stroke are not fully understood. There may be dissociation between metabolic activity and heat generation in ischemic brain. A systemic response to the increase in systemic inflammatory cytokines after stroke could also increase brain temperature. Interleukin-6 (IL-6) triggers the release of other proinflammatory 
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